This is one of the many reasons that liver volume measurement has attracted much attention, with more than 200 results in PubMed when searching for “liver volumetry.” Measuring liver volume, however, is time-consuming and cumbersome. Liver volume can be of prognostic value prior to liver surgery in certain patients. The regenerative capacity of the liver has been known since ancient times. Follow-up of liver volume is highly accurate with stereological methods.Measuring liver volume by stereology by 4-cm grids can be done in less than two minutes.Statistical methods can be used for measuring area/volume in radiology.Stereology employing 3- and 4-cm grids can rapidly provide accurate results for measuring liver volume and changes in liver volume. The mean time required for measurement by stereology was 59–190 s. The mean differences in liver volume between stereology based on 3-, 4-, 5-, and 6-cm grids and volumetry were 37, 3, 132, and 23 mL, respectively, and the differences in measurement of liver volume change were 21, 2, 19, and 76 mL, respectively. There was no significant difference in measurements between stereology methods and volumetry ( p > 0.05). The liver volume and the changes in volume before and after treatment were compared between stereology and volumetry. Grids of 3, 4, 5, and 6 cm were used to measure liver volume on different occasions by stereology. MRI was performed before and after different weight-reducing regimens. Liver volume was measured by volumetry in 41 sets of liver MRI. The purpose of this study was to test the stereology method using several grid sizes for measuring liver volume and to find which grid provides an accurate estimate of liver volume.
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